Abstract:The distribution sites of every species in Moraceae of China were gotten in the websites of Flora Reipubliace Popularis Sinicae, eFlora of China, National Specimen Information Infrastructure, and the relevant books and papers. The site is accurate to county of China. Geographic Information System is used in the paper. Spatial data with 12 genera of Moraceae is composed of every county. Spatial distribution map of genera is made. Spatial similarity coefficient is calculated. Spatial diversities and differences between genera in Moraceae are analyzed. (1) Morus is the most widely distributed in all genera and Maclura is the most narrowly distributed in China. (2) Spatial similarity coefficients between Maclura and other genera are low (0-0.044 4). The coefficients between Maclura and Antiaris, Malaisia are 0. These mean that there are little overlapping areas between Maclura and other genera in spatial distribution. The coefficients between Ficus and Broussonetia, Cudrania are 0.739 4, 0.679 5. This means that there are more overlapping areas between the three genera. The spatial distribution of the Antiaris is from tropical to subtropical region. (3) The diversity centers (protected areas) of all genera are in tropical and subtropical zones in Moraceae of China. Artocarpus and Humulus are in Yunnan, but Streblus is in Hainan. The diversity centers of Cudrania have expanded from tropical and south subtropics to middle subtropics. There are 98 species in Ficus of China. Diversity centers of Ficus are in southeast Gansu, northeast Guizhou, southern Yunnan, southwest Guangxi, southern Taiwan and western Hainan. There are 11 species in Morus of China. Diversity centers of Morus are in southern Chongqing, southern Hubei, northwest Hunan, central and southern Guizhou, eastern Yunnan and western Guangxi. The results suggest that diversity centers of genera in Moraceae of China have their own characteristics. It is more accurate to study on spatial distribution and diversity of Moraceae based on county, which can determine the minimum range to protect genera of Moraceae. The results support that centers of differentiation and transition in Morus are in Guizhou.