The study used fruit peel of sand pear (Pyrus pyrifolia Nakai) cultivars ‘Huanghua’ pear (russet fruit) and its bud mutant ‘Lühuanghua’ pear (green fruit) at 8 weeks after full bloom (WAFB) as experiment materials. the cDNA fulllength of HHT gene,which was named PpyHHT (GenBank accession No. KX131155), was cloned by conventional and nest PCR techniques. Sequence analysis showed that the fulllength of the PpyHHT ortholog consisted of a 1 335 bp open reading frame (ORF) encoding a polypeptide containing 444 amino acid residues. The molecular weight of deduced amino acids was 49.91 kD, with an isoelectric point (pI) of 4.75, which had the highest similarity (98%) and closest relationship with that in Pyrus bretschneideri. Realtime fluorescence quantitative PCR (qRTPCR) analysis demonstrated that the expression of PpyHHT gene in ‘Huanghua’ and ‘Lühuanghua’ pear peel were changing constantly during the key period (6-9 weeks), and significantly higher in ‘Huanghua’ pear peel than that in ‘Lühuanghua’. PpyHHT gene involved in the formation of sand pear russet/green traits, its expression level differences may play a role in the formation of sand pear skin color.